Antidepressants and survival in glioma – a registry-based retrospective cohort study

Abstract Background Depression and treatment with antidepressant medication is common in patients malignant glioma. However, the extent to which antidepressants may affect disease not fully understood. Therefore, purpose of present study was investigate possible associations between survival glioma patients. Methods We performed a registry-based cohort including 1231 (WHO grades 2, 3, 4) having undergone surgery, 6400 matched controls without All data were extracted from RISK North database, contains information multiple national population-based registries Sweden. Results Treatment more (27%), compared (16%), P < .001. after surgery for significantly associated poorer survival. These effects observed both selective serotonin reuptake inhibitors (SSRIs) non-SSRIs. In grade 4 glioma, SSRI hazard ratio (HR) 3.32 (95% CI 2.69–4.10, .001), non-SSRI HR 3.54 2.52–4.99, antidepressants. 2-3 3.26 2.19–4.85, 7.71 4.22–14.12, .001). Conclusions Our results demonstrate negative association Further research will be needed clarify causation.